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Algynomics - Personalized Pain Medications and Diagnostics

2009

  • Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009 May;10(5):447-85. Review. [Abstract]
  • Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). Neuroimage. 2009 Sep;47(3):1077-85. Epub 2009 Jun 6.  [Abstract]
  • Hollins M, Harper D, Gallagher S, Owings EW, Lim PF, Miller V, Siddiqi MQ, Maixner W. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis. Pain. 2009 Feb;141(3):215-21. Epub 2009 Jan 1. [Abstract]

  • King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley JL 3rd. Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder. Pain. 2009 Jun;143(3):172-8. Epub 2009 Mar 10. [Abstract]

  • Light KC, Bragdon EE, Grewen KM, Brownley KA, Girdler SS, Maixner W. Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain. 2009 May;10(5):542-52. [Abstract]

  • McLean SA, Kirsch NL, Tan-Schriner CU, Sen A, Frederiksen S, Harris RE, Maixner W, Maio RF. Health status, not head injury, predicts concussion symptoms after minor injury. Am J Emerg Med. 2009 Feb;27(2):182-90. [Abstract]

  • Nackley AG, Shabalina SA, Lambert JE, Conrad MS, Gibson DG, Spiridonov AN, Satterfield SK, Diatchenko L. Low enzymatic activity haplotypes of the human catechol-o-methyltransferase gene: enrichment for marker SNPs. PLoS ONE.2009 April 13; 4(5). [Abstract]

  • Nebel MB, Gracely RH. Neuroimaging of fibromyalgia. Rheum Dis Clin North Am. 2009 May;35(2):313-27. Review. [Abstract]

  • Ribeiro-Dasilva MC, Peres Line SR, Leme Godoy dos Santos MC, Arthuri MT, Hou W, Fillingim RB, Rizzatti Barbosa CM. Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder. J Pain. 2009 May;10(5):527-33. [Abstract]
  • Shabalina SA, Zaykin DV, Gris P, Ogurtsov AY, Gauthier J, Shibata K, Tchivileva IE, Belfer I, Mishra B, Kiselycznyk C, Wallace MR, Staud R, Spiridonov NA, Max MB, Goldman D, Fillingim RB, Maixner W, Diatchenko L. Expansion of the Human mu-Opioid Receptor Gene Architecture: Novel Functional Variants. Hum Mol Genet. 2009 Mar 15;18(6):1037-51. Epub 2008 Dec 22. [Abstract]
  • Tchivileva IE, Nackley AG, Qian L, Wentworth S, Conrad M, Diatchenko LB. Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase. Mol Pain. 2009 Mar 16;5:13. [Abstract]
  • Tchivileva IE, Tan KS, Gambarian M, Nackley AG, Medvedev AV, Romanov S, Flood PM, Maixner W, Makarov SS, Diatchenko L. Signaling pathways mediating beta 3 adrenergic receptor-induced production of interleukin-6 in adipocytes. Molecular Immunology. 2009, May 22. [Epub ahead of print]. [Abstract]

  • Wen S, Wang C, Berg A, Li Y, Chang MM, Fillingim RB, Wallace MR, Staud R, Kaplan L, Wu R. Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data. Algorithms Mol Biol. 2009 Aug 11;4:11. [Abstract]

  • Zhou Q, Fillingim RB, Riley JL 3rd, Verne GN. Thermal hypersensitivity in a subset of irritable bowel syndrome patients. World J Gastroenterol. 2009 Jul 14;15(26):3254-60. [Abstract]

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2008

  • Campbell CM, France CR, Robinson ME, Logan HL, Geffken GR, Fillingim RB. Ethnic differences in diffuse noxious inhibitory controls. J Pain. 2008 Aug;9(8):759-66. Epub 2008 May 14. [Abstract]
  • Campbell CM, France CR, Robinson ME, Logan HL, Geffken GR, Fillingim RB. Ethnic differences in the nociceptive flexion reflex (NFR) .Pain. 2008 Jan;134(1-2):91-6. [Abstract]

  • Fillingim RB, Wallace MR, Herbstman DM, Ribeiro-Dasilva M, Staud R. Genetic contributions to pain: a review of findings in humans. Oral Dis. 2008 Nov;14(8):673-82. Review. [Abstract]

  • Geisser ME, Glass JM, Rajcevska LD, Clauw DJ, Williams DA, Kileny PR, Gracely RH. A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain. 2008 May;9(5):417-22. Epub 2008 Feb 15. [Abstract]
  • Geisser ME, Strader Donnell C, Petzke F, Gracely RH, Clauw DJ, Williams DA. Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism. Psychosomatics. 2008 May-Jun;49(3):235-42. [Abstract]
  • George SZ, Dover GC, Wallace MR, Sack BK, Herbstman DM, Aydog E, Fillingim RB. Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings. Clin J Pain. 2008 Nov-Dec;24(9):793-801. [Abstract]
  • George SZ, Wallace MR, Wright TW, Moser MW, Greenfield WH 3rd, Sack BK, Herbstman DM, Fillingim RB. Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings. Pain. 2008 May;136(1-2):53-61. [Abstract]
  • Harris RE, Sundgren PC, Pang Y, Hsu M, Petrou M, Kim SH, McLean SA, Gracely RH, Clauw DJ.  Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum. 2008 Mar;58(3):903-7. [Abstract]
  • Hollins M, Harper D, Gallagher S, Owings EW, Lim PF, Miller V, Siddiqi MQ, Maixner W. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: An evaluation of the generalized hypervigilance hypothesis. Pain. 2008 Dec 31. [Abstract]
  • Komiyama O, Gracely RH, Kawara M, Laat AD.  Intraoral measurement of tactile and filament-prick pain threshold using shortened Semmes-Weinstein monofilaments. Clin J Pain. 2008 Jan;24(1):16-21. [Abstract]
  • Petrou M, Harris RE, Foerster BR, McLean SA, Sen A, Clauw DJ, Sundgren PC. Proton MR spectroscopy in the evaluation of cerebral metabolism in patients with fibromyalgia: comparison with healthy controls and correlation with symptom severity. Am J Neuroradiol. 2008 May;29(5):913-8. Epub 2008 Mar 13. [Abstract]
  • Romanov S, Medvedev A, Gambarian M, Poltoratskaya N, Moeser M, Medvedeva L, Gambarian M, Diatchenko L, Makarov S. Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors. Nat Methods. 2008 Mar;5(3):253-60. Epub 2008 Feb 24. [Abstract]
  • Shibata K, Diatchenko L, Zaykin DV.  Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. Genet Epidemiol. 2008 Jul 17;33(1):63-78. [Abstract] 
  • Slade GD, Diatchenko L, Ohrbach R, Maixner W. Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod. 2008 Jun;14(2):146-156. [Abstract]
  • Wang C, Cheng Y, Liu T, Li Q, Fillingim RB, Wallace MR, Staud R, Kaplan L, Wu R.  A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity. Mol Pain. 2008 Apr 16;4:13. [Abstract]
  • Zolnoun DA, Rohl J, Moore CG, Perinetti-Liebert C, Lamvu GM, Maixner W.  Overlap between orofacial pain and vulvar vestibulitis syndrome. Clin J Pain. 2008 Mar-Apr;24(3):187-91. [Abstract]

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2007

  • Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W. Genetic architecture of human pain perception. Trends Genet 2007; 23:605-13. [Abstract]
  • Diatchenko L, Slade GD, Nackley AG, Maixner W. Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-24. Pain. 2007 Jun;129(3):366-370. [Abstract]
  • Edwards RR, Fillingim RB. Self-reported pain sensitivity: lack of correlation with pain threshold and tolerance. Eur J Pain. 2007 Jul;11(5):594-8. [Abstract]
  • Geisser ME, Gracely RH, Giesecke T, Petzke FW, Williams DA, Clauw DJ. The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome. Eur J Pain 2007; 11: 202-7. [Abstract]
  • George SZ, Wittmer VT, Fillingim RB, Robinson ME. Sex and pain-related psychological variables are associated with thermal pain sensitivity for patients with chronic low back pain. J Pain. 2007 Jan;8(1):2-10. [Abstract]
  • Gracely RH. A pain psychologist's view of tenderness in fibromyalgia. J Rheumatol. 2007 May;34(5):912-3. [Abstract]
  • Greenspan JD, Craft RM, LeResche L, et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007 Nov;132 Suppl 1:S26-45. [Abstract]
  • Hadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK, Williams J. An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin J Pain. 2007 Jan;23(1 Suppl):S1-43. [Abstract]
  • Harris RE, Clauw DJ, Scott DJ, McLean SA, Gracely RH, Zubieta JK. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci 2007; 27:10000-6. [Abstract]
  • Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 2007; 128: 199-208. [Abstract]
  • Rahim-Williams FB, Riley JL 3rd, Herrera D, Campbell CM, Hastie BA, Fillingim RB. Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics. Pain. 2007 May;129(1-2):177-84. [Abstract]
  • Reed BD, Sen A, Gracely RH. Effect of test order on sensitivity in vulvodynia. J Reprod Med 2007; 52:199-206. [Abstract]
  • Shinal RM, Fillingim RB. Overview of orofacial pain: epidemiology and gender differences in orofacial pain. Dent Clin North Am. 2007 Jan;51(1):1-18, v. [Abstract]   
  • Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, Max MB, Goldman D, Maixner W. Influence of psychological factors on risk of temporomandibular disorders. J Dent Res. 2007 Nov;86(11):1120-5. [Abstract]
  • Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, Flood PM. Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal. 2007 Feb;19(2):251-60. [Abstract]

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2006

  • Diatchenko L, Anderson AD, Slade GD, et al. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 2006; 141:449-62. [Abstract]
  • Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W. Idiopathic pain disorders — pathways of vulnerability. Pain 2006; 123:226-30. [Abstract]
  • Diatchenko L, Nackley AG, Slade GD, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125:216-24. [Abstract]
  • Harris RE, Gracely RH, McLean SA, et al. Comparison of clinical and evoked pain measures in fibromyalgia. J Pain 2006; 7: 521-7. [Abstract]
  • McLean SA, Williams DA, Stein PK, et al. Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. Neuropsychopharmacology 2006; 31:2776-82. [Abstract]
  • Nackley A, Diatchenko L, Maixner W. Perspectives on the genetic basis of opioid-induced hyperalgesia. Anesthesiology 2006; 104:909-10. [Abstract]
  • Nackley AG, Shabalina SA, Tchivileva IE, et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 2006; 314:1930-3. [Abstract]
  • Price DD, Fillingim RB, Robinson ME. Placebo analgesia: friend or foe? Curr Rheumatol Rep 2006; 8: 418-24. [Abstract]
  • Staud R, Price DD, Fillingim RB. Advanced continuous-contact heat pulse design for efficient temporal summation of second pain (windup). J Pain. 2006 Aug;7(8):575-82. [Abstract]
  • Tegeder I, Costigan M, Griffin RS,Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006; 12:1269-77. [Abstract]
  • Williams DA, Gracely RH. Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia. Arthritis Res Ther. 2006;8(6):224. [Abstract]

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2005

  • Bhalang K, Sigurdsson A, Slade GD, Maixner W. Associations among four modalities of experimental pain in women. J Pain 2005; 6:604-11. [Abstract]
  • Campbell CM, Edwards RR, Fillingim RB. Ethnic differences in responses to multiple experimental pain stimuli. Pain. 2005 Jan;113(1-2):20-6. [Abstract]
  • Diatchenko L, Romanov S, Malinina I, Clarke J, Tchivilev I, Li X, Makarov SS. Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes. J Leukoc Biol. 2005 Dec;78(6):1366-77. [Abstract]
  • Diatchenko L, Slade GD, Nackley AG, et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005; 14:135-43. [Abstract]
  • Fillingim RB. Individual differences in pain responses. Curr Rheumatol Rep 2005 Oct;7(5):342-7. [Abstract]
  • Fillingim RB, Kaplan L, Staud R, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 2005; 6:159-67. [Abstract]
  • Fillingim RB, Price DD. What is controlled for in placebo-controlled trials? Mayo Clin Proc 2005; 80:1119-21. [Abstract]
  • Gendreau RM, Thorn MD, Gendreau JF, et al. Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol 2005; 32:1975-85. [Abstract]
  • Giesecke T, Gracely RH, Williams DA, Geisser ME, Petzke FW, Clauw DJ. The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum. 2005 May;52(5):1577-84. [Abstract]
  • Hastie BA, Riley JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Med. 2005 Jan-Feb;6(1):61-71. [Abstract]
  • Hastie BA, Riley JL 3rd, Robinson ME, Glover T, Campbell CM, Staud R, Fillingim RB. Cluster analysis of multiple experimental pain modalities. Pain 2005; 116:227-37. [Abstract]
  • McLean SA, Williams DA, Harris RE, et al. Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum 2005; 52:3660-9. [Abstract]
  • Mogil JS, Ritchie J, Smith SB, Strasburg K, Kaplan L, Wallace MR, Romberg RR, Bijl H, Sarton EY, Fillingim RB, Dahan A. Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. J Med Genet 2005 Jul;42(7):583-7. [Abstract]
  • Ness TJ, Powell-Boone T, Cannon R, Lloyd LK, Fillingim RB. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol 2005 Jun;173(6):1983-7. [Abstract]
  • Petzke F, Harris RE, Williams DA, Clauw DJ, Gracely RH. Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls. Eur J Pain 2005; 9:325-35. [Abstract]
  • Robinson ME, Brown JL, George SZ, Edwards PS, Atchison JW, Hirsh AT, Waxenberg LB, Wittmer V, Fillingim RB. Multidimensional success criteria and expectations for treatment of chronic pain: the patient perspective. Pain 2005 Sep-Oct;6(5):336-45. [Abstract]

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2004

  • Eliav E, Gracely RH, Nahlieli O, Benoliel R. Quantitative sensory testing in trigeminal nerve damage assessment. J Orofac Pain 2004; 18:339-44. [Abstract]
  • Giesecke J, Reed BD, Haefner HK, Giesecke T, Clauw DJ, Gracely RH. Quantitative sensory testing in vulvodynia patients and increased peripheral pressure pain sensitivity. Obstet Gynecol 2004; 104:126-33. [Abstract]
  • Giesecke T, Gracely RH, Grant MA, et al. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum 2004; 50:613-23. [Abstract]
  • Gracely RH, Geisser ME, Giesecke T, Grant MA, Petzke F, Williams DA, Clauw DJ. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004 Apr;127(Pt 4):835-43. [Abstract]
  • Williams DA, Farrell MJ, Cunningham J, Gracely RH, Ambrose K, Cupps T, Mohan N, Clauw DJ. Knee pain and radiographic osteoarthritis interact in the prediction of levels of self-reported disability.Arthritis Rheum. 2004 Aug 15;51(4):558-61. [Abstract]
  • Williams DA, Gendreau M, Hufford MR, Groner K, Gracely RH, Clauw DJ. Pain assessment in patients with fibromyalgia syndrome: a consideration of methods for clinical trials. Clin J Pain 2004; 20:348-56. [Abstract]

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2003

  • Edwards RR, Doleys DM, Lowery D, Fillingim RB. Pain tolerance as a predictor of outcome following multidisciplinary treatment for chronic pain: differential effects as a function of sex. Pain 2003; 106:419-26. [Abstract]
  • Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables.Pain. 2003 Dec;106(3):427-37. [Abstract]
  • Fillingim RB. Hyperalgesia versus response bias in fibromyalgia. Pain. 2003 Oct;105(3):385-6. [Abstract]
  • Giesecke T, Williams DA, Harris RE, et al. Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum 2003; 48:2916-22. [Abstract]
  • Gracely RH, Grant MA, Giesecke T. Evoked pain measures in fibromyalgia. Best Pract Res Clin Rheumatol 2003; 17:593-609. [Abstract]
  • McLean SA, Gracely RH. Visual analog pain scores and the need for analgesia. Acad Emerg Med 2003; 10:1012-3; author reply 3. [Abstract]
  • Petzke F, Clauw DJ, Ambrose K, Khine A, Gracely RH. Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation. Pain 2003; 105:403-13. [Abstract]

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