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Algynomics - Personalized Pain Medications and Diagnostics

2010

 

Abstracts presented at the 13th World Congress on Pain, International Association for the Study of Pain, Montreal, Quebec, Canada 2010:

W. Maixner, S. B. Smith, T. Bhangale, B. Weir, C. Hyde, G. Slade, S. L. John, S. A. McLean, R. H. Gracely, K. Ambrose, K. Tan, J. Jordan, L. Diatchenko. Initial identification of genetic variants associated with painful osteoarthritis - Results from a community based genome-wide association study. [Abstract]

S. B. Smith, R. B. Fillingim, W. Maixner, C. Hyde, G. Slade, S. L. John, S. A. McLean, R. H. Gracely, D. Zaykin, I. Mazo, A. Yuryev, I. Tchivileva, K. Tan, L. Diatchenko. Multivariate factor analysis and genetic association provide evidence for clinical heterogeneity in fibromyalgia. [Abstract]

R. H. Gracely, S. B. Smith, G. Slade, L. Diatchenko, R. B. Fillingim, B. Fijal, E. Frakes, S. A. McLean, K. Piezer, A. N. Heinloth, W. Maixner, J. P. Houston. Association of genetic polymorphisms with placebo treatment in patients with osteoarthritis knee pain. [Abstract]

Peer-reviewed publications:

  • Gris P, Cheng P, Pierson J, Maixner W, Diatchenko L. Molecular Assays for Characterization of Alternatively Spliced Isoforms of the Mu Opioid Receptor (MOR). Methods Mol Biol. 2010;617:421-35. [Abstract]

  • Gris P, Gauthier J, Cheng P, Gibson DG, Gris D, Laur O, Pierson J, Wentworth S, Nackley AG, Maixner W, Diatchenko L. A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Molecular Pain 2010, Jun 2;6(1):33. [Abstract]

  • Heymen S, Maixner W, Whitehead WE, Klatzkin RR, Mechlin B, Light KC. Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controls. Clin J Pain. 2010 Feb;26(2):104-9. [Abstract]

  • Jensen KB, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Mainguy Y, Gracely R, Ingvar M, Kosek E. Anxiety and depressive symptoms in Fibromyalgia are related to low health esteem but not to pain sensitivity or cerebral processing of pain. Arthritis Rheum. 2010 Jul 8. [Epub ahead of print] [Abstract]

  • Kindler LL, Valencia C, Fillingim RB, George SZ. Sex differences in experimental and clinical pain sensitivity for patients with shoulder pain. Eur J Pain. 2010 Jun 30. [Epub ahead of print] [Abstract]

  • Lim PF, Smith S, Bhalang K, Slade GD, Maixner W. Development of temporomandibular disorders is associated with greater bodily pain experience. Clin J Pain. 2010 Feb;26(2):116-20. PubMed Central PMCID:  PMC2811336. [Abstract]

  • Nackley AG, Diatchenko L. Assessing Potential Functionality of Catechol-O-methyltransferase (COMT) Polymorphisms Associated with Pain Sensitivity and Temporomandibular Joint Disorders. Methods Mol Biol. 2010;617:375-93. [Abstract]

  • Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin DV, McHale DP, Drenth JP, Dai F, Wheeler J, Sanders F, Wood L, Wu TX, Karppinen J, Nikolajsen L, Männikkö M, Max MB, Kiselycznyk C, Poddar M, Te Morsche RH, Smith S, Gibson D, Kelempisioti A, Maixner W, Gribble FM, Woods CG. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5148-53. Epub 2010 Mar 8. PubMed Central PMCID: PMC2841869. [Abstract]

  • Riley JL 3rd, King CD, Wong F, Fillingim RB, Mauderli AP. Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults. Pain. 2010 May 21. [Epub ahead of print]. [Abstract]

  • Segall S, Nackley AG, Diatchenko L, Lariviere WR, Lu X, Marron JS, Grabowski-Boase L, Walker JR, Slade G, Gauthier J, Bailey JS, Steffy BM, Maynard TM, Tarantino LM, Wiltshire T. Comt1 Genotype and Expression Predicts Anxiety and Nociceptive Sensitivity in Inbred Strains of Mice. Genes Brain Behav. 2010 Jul 23. [Epub ahead of print] [Abstract]

  • Tchivileva IE, Lim PF, Smith SB, Slade GD, Diatchenko L, McLean SA, Maixner W. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics. 2010 Apr;20(4):239-48. [Abstract]

  • Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010 Apr;14(4):339. Epub 2010 Mar 12. No abstract available.

  • Zhou Q, Fillingim RB, Riley JL 3rd, Malarkey WB, Verne GN. Central and peripheral hypersensitivity in the irritable bowel syndrome. Pain. 2010 Mar;148(3):454-61. Epub 2010 Jan 13. [Abstract]

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2009

  • Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009 May;10(5):447-85. Review. [Abstract]
  • Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). Neuroimage. 2009 Sep;47(3):1077-85. Epub 2009 Jun 6.  [Abstract]
  • Hollins M, Harper D, Gallagher S, Owings EW, Lim PF, Miller V, Siddiqi MQ, Maixner W. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis. Pain. 2009 Feb;141(3):215-21. Epub 2009 Jan 1. [Abstract]

  • King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley JL 3rd. Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder. Pain. 2009 Jun;143(3):172-8. Epub 2009 Mar 10. [Abstract]

  • Light KC, Bragdon EE, Grewen KM, Brownley KA, Girdler SS, Maixner W. Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain. 2009 May;10(5):542-52. [Abstract]

  • McLean SA, Kirsch NL, Tan-Schriner CU, Sen A, Frederiksen S, Harris RE, Maixner W, Maio RF. Health status, not head injury, predicts concussion symptoms after minor injury. Am J Emerg Med. 2009 Feb;27(2):182-90. [Abstract]

  • Nackley AG, Shabalina SA, Lambert JE, Conrad MS, Gibson DG, Spiridonov AN, Satterfield SK, Diatchenko L. Low enzymatic activity haplotypes of the human catechol-o-methyltransferase gene: enrichment for marker SNPs. PLoS ONE.2009 April 13; 4(5). [Abstract]

  • Nebel MB, Gracely RH. Neuroimaging of fibromyalgia. Rheum Dis Clin North Am. 2009 May;35(2):313-27. Review. [Abstract]

  • Ribeiro-Dasilva MC, Peres Line SR, Leme Godoy dos Santos MC, Arthuri MT, Hou W, Fillingim RB, Rizzatti Barbosa CM. Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder. J Pain. 2009 May;10(5):527-33. [Abstract]
  • Shabalina SA, Zaykin DV, Gris P, Ogurtsov AY, Gauthier J, Shibata K, Tchivileva IE, Belfer I, Mishra B, Kiselycznyk C, Wallace MR, Staud R, Spiridonov NA, Max MB, Goldman D, Fillingim RB, Maixner W, Diatchenko L. Expansion of the Human mu-Opioid Receptor Gene Architecture: Novel Functional Variants. Hum Mol Genet. 2009 Mar 15;18(6):1037-51. Epub 2008 Dec 22. [Abstract]
  • Tchivileva IE, Nackley AG, Qian L, Wentworth S, Conrad M, Diatchenko LB. Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase. Mol Pain. 2009 Mar 16;5:13. [Abstract]
  • Tchivileva IE, Tan KS, Gambarian M, Nackley AG, Medvedev AV, Romanov S, Flood PM, Maixner W, Makarov SS, Diatchenko L. Signaling pathways mediating beta 3 adrenergic receptor-induced production of interleukin-6 in adipocytes. Molecular Immunology. 2009, May 22. [Epub ahead of print]. [Abstract]

  • Thieme K, Gracely RH. Are psychological treatments effective for fibromyalgia pain? Curr Rheumatol Rep. 2009 Dec;11(6):443-50. Review.  PubMed PMID: 19922735. [Abstract]

  • Wen S, Wang C, Berg A, Li Y, Chang MM, Fillingim RB, Wallace MR, Staud R, Kaplan L, Wu R. Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data. Algorithms Mol Biol. 2009 Aug 11;4:11. [Abstract]

  • Zhou Q, Fillingim RB, Riley JL 3rd, Verne GN. Thermal hypersensitivity in a subset of irritable bowel syndrome patients. World J Gastroenterol. 2009 Jul 14;15(26):3254-60. [Abstract]

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2008

  • Campbell CM, France CR, Robinson ME, Logan HL, Geffken GR, Fillingim RB. Ethnic differences in diffuse noxious inhibitory controls. J Pain. 2008 Aug;9(8):759-66. Epub 2008 May 14. [Abstract]
  • Campbell CM, France CR, Robinson ME, Logan HL, Geffken GR, Fillingim RB. Ethnic differences in the nociceptive flexion reflex (NFR) .Pain. 2008 Jan;134(1-2):91-6. [Abstract]

  • Fillingim RB, Wallace MR, Herbstman DM, Ribeiro-Dasilva M, Staud R. Genetic contributions to pain: a review of findings in humans. Oral Dis. 2008 Nov;14(8):673-82. Review. [Abstract]

  • Geisser ME, Glass JM, Rajcevska LD, Clauw DJ, Williams DA, Kileny PR, Gracely RH. A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain. 2008 May;9(5):417-22. Epub 2008 Feb 15. [Abstract]
  • Geisser ME, Strader Donnell C, Petzke F, Gracely RH, Clauw DJ, Williams DA. Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism. Psychosomatics. 2008 May-Jun;49(3):235-42. [Abstract]
  • George SZ, Dover GC, Wallace MR, Sack BK, Herbstman DM, Aydog E, Fillingim RB. Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings. Clin J Pain. 2008 Nov-Dec;24(9):793-801. [Abstract]
  • George SZ, Wallace MR, Wright TW, Moser MW, Greenfield WH 3rd, Sack BK, Herbstman DM, Fillingim RB. Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings. Pain. 2008 May;136(1-2):53-61. [Abstract]
  • Harris RE, Sundgren PC, Pang Y, Hsu M, Petrou M, Kim SH, McLean SA, Gracely RH, Clauw DJ.  Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum. 2008 Mar;58(3):903-7. [Abstract]
  • Hollins M, Harper D, Gallagher S, Owings EW, Lim PF, Miller V, Siddiqi MQ, Maixner W. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: An evaluation of the generalized hypervigilance hypothesis. Pain. 2008 Dec 31. [Abstract]
  • Komiyama O, Gracely RH, Kawara M, Laat AD.  Intraoral measurement of tactile and filament-prick pain threshold using shortened Semmes-Weinstein monofilaments. Clin J Pain. 2008 Jan;24(1):16-21. [Abstract]
  • Petrou M, Harris RE, Foerster BR, McLean SA, Sen A, Clauw DJ, Sundgren PC. Proton MR spectroscopy in the evaluation of cerebral metabolism in patients with fibromyalgia: comparison with healthy controls and correlation with symptom severity. Am J Neuroradiol. 2008 May;29(5):913-8. Epub 2008 Mar 13. [Abstract]
  • Romanov S, Medvedev A, Gambarian M, Poltoratskaya N, Moeser M, Medvedeva L, Gambarian M, Diatchenko L, Makarov S. Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors. Nat Methods. 2008 Mar;5(3):253-60. Epub 2008 Feb 24. [Abstract]
  • Shibata K, Diatchenko L, Zaykin DV.  Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. Genet Epidemiol. 2008 Jul 17;33(1):63-78. [Abstract] 
  • Slade GD, Diatchenko L, Ohrbach R, Maixner W. Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod. 2008 Jun;14(2):146-156. [Abstract]
  • Wang C, Cheng Y, Liu T, Li Q, Fillingim RB, Wallace MR, Staud R, Kaplan L, Wu R.  A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity. Mol Pain. 2008 Apr 16;4:13. [Abstract]
  • Zolnoun DA, Rohl J, Moore CG, Perinetti-Liebert C, Lamvu GM, Maixner W.  Overlap between orofacial pain and vulvar vestibulitis syndrome. Clin J Pain. 2008 Mar-Apr;24(3):187-91. [Abstract]

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2007

  • Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W. Genetic architecture of human pain perception. Trends Genet 2007; 23:605-13. [Abstract]
  • Diatchenko L, Slade GD, Nackley AG, Maixner W. Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-24. Pain. 2007 Jun;129(3):366-370. [Abstract]
  • Edwards RR, Fillingim RB. Self-reported pain sensitivity: lack of correlation with pain threshold and tolerance. Eur J Pain. 2007 Jul;11(5):594-8. [Abstract]
  • Geisser ME, Gracely RH, Giesecke T, Petzke FW, Williams DA, Clauw DJ. The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome. Eur J Pain 2007; 11: 202-7. [Abstract]
  • George SZ, Wittmer VT, Fillingim RB, Robinson ME. Sex and pain-related psychological variables are associated with thermal pain sensitivity for patients with chronic low back pain. J Pain. 2007 Jan;8(1):2-10. [Abstract]
  • Gracely RH. A pain psychologist's view of tenderness in fibromyalgia. J Rheumatol. 2007 May;34(5):912-3. [Abstract]
  • Greenspan JD, Craft RM, LeResche L, et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007 Nov;132 Suppl 1:S26-45. [Abstract]
  • Hadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK, Williams J. An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin J Pain. 2007 Jan;23(1 Suppl):S1-43. [Abstract]
  • Harris RE, Clauw DJ, Scott DJ, McLean SA, Gracely RH, Zubieta JK. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci 2007; 27:10000-6. [Abstract]
  • Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 2007; 128: 199-208. [Abstract]
  • Rahim-Williams FB, Riley JL 3rd, Herrera D, Campbell CM, Hastie BA, Fillingim RB. Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics. Pain. 2007 May;129(1-2):177-84. [Abstract]
  • Reed BD, Sen A, Gracely RH. Effect of test order on sensitivity in vulvodynia. J Reprod Med 2007; 52:199-206. [Abstract]
  • Shinal RM, Fillingim RB. Overview of orofacial pain: epidemiology and gender differences in orofacial pain. Dent Clin North Am. 2007 Jan;51(1):1-18, v. [Abstract]   
  • Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, Max MB, Goldman D, Maixner W. Influence of psychological factors on risk of temporomandibular disorders. J Dent Res. 2007 Nov;86(11):1120-5. [Abstract]
  • Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, Flood PM. Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal. 2007 Feb;19(2):251-60. [Abstract]

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2006

  • Diatchenko L, Anderson AD, Slade GD, et al. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 2006; 141:449-62. [Abstract]
  • Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W. Idiopathic pain disorders — pathways of vulnerability. Pain 2006; 123:226-30. [Abstract]
  • Diatchenko L, Nackley AG, Slade GD, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125:216-24. [Abstract]
  • Harris RE, Gracely RH, McLean SA, et al. Comparison of clinical and evoked pain measures in fibromyalgia. J Pain 2006; 7: 521-7. [Abstract]
  • McLean SA, Williams DA, Stein PK, et al. Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. Neuropsychopharmacology 2006; 31:2776-82. [Abstract]
  • Nackley A, Diatchenko L, Maixner W. Perspectives on the genetic basis of opioid-induced hyperalgesia. Anesthesiology 2006; 104:909-10. [Abstract]
  • Nackley AG, Shabalina SA, Tchivileva IE, et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 2006; 314:1930-3. [Abstract]
  • Price DD, Fillingim RB, Robinson ME. Placebo analgesia: friend or foe? Curr Rheumatol Rep 2006; 8: 418-24. [Abstract]
  • Staud R, Price DD, Fillingim RB. Advanced continuous-contact heat pulse design for efficient temporal summation of second pain (windup). J Pain. 2006 Aug;7(8):575-82. [Abstract]
  • Tegeder I, Costigan M, Griffin RS,Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006; 12:1269-77. [Abstract]
  • Williams DA, Gracely RH. Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia. Arthritis Res Ther. 2006;8(6):224. [Abstract]

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